The home side opened the scoring inside the opening ten minutes. A free kick from the left bounced around inside the box before falling to Gary Smith just inside the area and a low drive found its way into the bottom corner.
SLough responded instantly, moving the ball around well on a surface far better than they had been accustomed to playing on. Mark Avery fed the ball into Glen Harris who in turn played the ball into the run of Ian Hodges. With a flick of the outside of his right foot, he steered the ball low past Robert Webb and into the net.
Serge Makofo's pace took him past both Avery and Steve Daly and he slid the ball across for Sam Baldock, but a mix of defenders and keeper kept the ball out. At the other end, Garath McCleary dribbled between two before hitting a low cross into the middle but Andy Ballard could not get a touch when well placed in the centre.
MK got themselves back in front after twenty six minutes. Malvin Kamara's pace took him clear and his effort thundered back off the underside of the bar but Makofo was on hand to steer the ball home after Aaron Steele failed to clear and put the home side 2-1 up.
Smith added a third six minutes later with a well worked free kick routine which gave him space to pick his spot from the edge of the area, and as he had done with the opening goal, hit a low drive into the same corner.
Slough were still playing well and moving the ball between their attacking players in neat patterns when they did get forward. One move saw McCleary square into Harris in the middle who in turn fed into the run of Leigh Mason down the left and the midfielder tested Webb with a strong drive which was pushed away.
Slough had the better of the opening exchanges at the start of the second half with an Andy Ballard long throw being flicked just over their own bar by the MK Dons defence and then Hodges bundled Webb over as he claimed a high ball as the ball ended up in the net but was correctly ruled out.
However, the pace and trickery of the MK Dons attack began to bear fruit as they hit three more goals without reply in the remainder of the half. Baldock and Makofo in particular were causing no end of issues with their pace and ability on and off the ball. Baldock scored a wonderful individual goal, ghosting around four Slough defenders before slotting past Carbon for the fourth.
McCleary, as has been so often the case this season, looked the Rebels best outlet and the winger tested Webb with a strong drive from twenty yards but the keeper was able to turn it round the post.
Poor defending from Slough saw them conceded a fifth. Darron Wilkinson passed back to Daly, on his own six yard line, and the captain's clearance was poor, falling straight to Nick McKoy. The midfielder set himself with a forward touch and then bent one low into the bottom corner.
Makofo deservedly got himself onto the scoresheet in the final minute as he cut inside from the right, rounded Parkin and then picked his spot past the covering Carbon.
MK Dons Line up
Robert Webb, Joe Howe, Sam Collins, Nick McKoy, Leon Crooks, Devon Williams, Malvin Kamara, Gary Smith, Sam Baldock, Serge Makofo, Nicky Rizzo. Subs: James Nash (for Collins), Ross Morley (for McKoy), Jamie England (for Makofo), Ryan Flood, Ted Day.