Slough opened the scoring in the eighth minute as a long Michael Parkin free kick was flicked on by Ian Hodges. The ball went to Glen Harris who moved the ball inside and then fired a beautiful looping volley into the far corner.
Oxford's response was instant with Ray Spence equalising within a minute for the visitors. Oxford won the ball back and Andy Ballard was caught under the bounce of the ball allowing Spence to twist inside Steve Daly and fire low into the net.
Hodges had a good headed chance to restore Slough's advantage but Carl Wilkins was equal to it and palmed his effort over the bar. Wilkins again pulled off a good save as Matt Seedel laid the ball to Harris on the edge of the area and the midfielder lined up a curling effort into the far corner. The ball took a deflection and looped up and Wilkins did well to readjust and push it over.
The second half saw Slough continue to be the dominant team as Josias Carbon fired wide from the right side of the area. Ten minutes into the second half, the wing back did get onto the scoresheet. Receiving the ball on the run into the area from Hodges, Carbon sidefooted across goal from a narrow angle and into the far corner.
Oxford very nearly repeated the immediate response they showed following the first goal as they again went close. Fortunately for Slough, their effort this time came back off the underside of the bar before Daly cleared.
With seventy five minutes gone, Slough extended their lead. Leon Woodruffe received the ball on the left and his cross was centred by Carbon at the back post into the path of sub Michael Alexis who converted from six yards.
Slough were firmly on top and further extended their lead ten minutes later as Carbon rode through a number of Oxford challenges to put the ball past Wilkins near post. Oxford were left hanging on for the final few minutes as Slough continued to press forward but could not take any further chances.
Oxford City Line up
Carl Wilkins, Craig Dore, Dominic Green, Andy Marriott, Jon Steedman, Adam Durrant, Justin Merritt, Matt Brandish, Harry Burnley, Danny Keen, Ray Spence. Subs: Omar Takriti(for Green), Ian Roper (for Burnley), Ryan McCulloch (for Keen), Stuart Douglas, Luke Brandon