Neil Baker and Jon Underwood’s side had to come from behind again to win the three points though, but recovered well after falling behind in the first half.
Scott Davies came straight into the starting line-up after joining from Chelmsford City earlier in the week, with James Dobson dropping to the bench. Guy Hollis also returned in place of Josh Jackman, whilst the injured Chris Flood was replaced by Ben Harris, making his first start since early February.
The first half was dominated by the away side, whose first chance arrived on four minutes when Lee Togwell’s strike was blocked and Ben Harris was denied by a fantastic save from young goalkeeper Tom Smith - who was drafted in late after first team stopper Tim Trebes was ruled out with illness.
Slough continued to get into good positions and play crosses into the St Ives box, and Warren Harris fired a fierce drive across the face of goal on 13 minutes after combining well with Manny Williams. Smith was called upon again two minutes later to turn over a header from Ben Harris, who rose to meet Nathan Smart's deep cross. It was a fantastic save from Smith, who flung himself high to his right to divert the ball over.
Davies and Simon Dunn fired efforts off target as Slough remained on top, but against the run of play the hosts took the lead on 27 minutes.
St Ives had been under the cosh for the majority of the time, but launched their first meaningful attack and Rogan McGeorge set Dubi Ogbonna running clear. Turner did well to block the striker's effort but could do nothing to prevent Peter Clark sliding in to turn the loose ball home from close range.
The game settled into something of a lull with Slough unable to rediscover their early threat, and St Ives had a penalty appeal turned down with Phil Draycott claiming he was fouled by Smart in the box.
Three minutes before the interval the Rebels drew level when this time a penalty was awarded in favour of the away side. Togwell fed Ben Harris, who was bundled over by Lloyd Groves as he prepared to shoot. Referee Jack Bloxham awarded the spot kick and Simon Dunn stepped up to score his fifth goal of the season.
Slough almost immediately took the lead when Togwell took aim with a volley from distance, but Smith was equal to it with another fantastic save.
However, the Rebels did find a second goal before half time when Warren Harris unleashed an unstoppable volley from 30 yards which flew into the top corner, giving Smith no chance – a contender for goal of the season and the winger's 40th for the club.
And the Rebels added a third early in the second period when Ben Harris headed in after Dunn had nodded a Warren Harris cross back into the middle, giving his side the kind of cushion their overall play had deserved.
St Ives continued to battle but were held off well by Slough, who continued to fashion the better chances. George Wells drove forward from full-back and combined well with Dunn to tee up substitute Perry Coles, whose two well-struck efforts were blocked.
Smith made another important save on 69 minutes when he dived to his left to keep out a powerful low 25-yarder from Wells - and moments later made a reaction save to prevent the ball flying in following a Guy Hollis long throw.
Togwell hit a post later in the half as Slough looked for a fourth, and Smith made another good save from Coles.
Smith was finally beaten again when Slough wrapped up the scoring deep into stoppage time. Davies fed James Dobson, and the winger's powerful low drive was kept out by Smith but only for Manny Williams to force home the loose ball from close range, scoring his first goal in 12 games in the process.
St Ives Town Line up
Tom Smith, Miles Smith, Luke Warner-Eley, Charlie De'ath (c), Lloyd Groves, Rogan McGeorge, Ben Baker, Ollie Snaith, Dubi Ogbonna, Peter Clark, Phil Draycott. Substitutes: Dan Moyes, Eugene Libertucci, Danny Watson, Danny Kelly, Declan Rogers.