Slough opened up the game well with chances falling to both Sonner and Sippetts with the latter forcing Matt Evans in the Lancing goal into a smart save low to his right.
Similar to last weeks league encounter with Hitchin, an early dismissal played a large part in the game with Lancing losing John Elliott after reacting to a late tackle from Adam Logie which also saw the Rebels midfielder booked.
Until this point, the two sides looked relatively even on an immaculate Culver Road playing surface. Lancing, clearly buoyed by their excellent start to their league campaign, were not able to test Jamie Jackson in the Slough goal, but were having more than their fair share of the play until the dismissal.
With the home side down to ten men, Slough were working the ball around well and forged an opening from a set piece. Sonner was fouled on the right hand side of the area and from the resulting free kick, Swift swung the ball into the back post to be met by the head of Seeby and into the net.
The home side had a great chance to get straight back into the game as the ball was worked to the back post where Garnham fired over when well placed.
Slough pressed forwards, making the most of their extra man advantage, and worked the ball to Logie on the edge of the box. The former Wealdstone man, making his first start for the Rebels, made no mistake from twenty yards and found the opposite corner with a neat strike.
Lancing continued to play neat concise football and despite being a man down were still causing problems for the higher league opponents with Garnham in particular providing some excellent link play for the home side. It was Garnham who pulled his side back into the game shortly before half time when he found space between Yeboah and Seeby to plant a header past Jackson and change the half time team talks for the respective sides.
The second half saw two further dismissals with Slough's Sonner being sent from the field of play for a high sliding challenge to be followed shortly after by a Lancing player for use of the elbow on Danny Murphy.
With more space opening up on the pitch and the home side having to press more men forwards to find an equaliser, Slough were finding more space in the Lancing half and with Paul Coyne spraying the ball around in midfield, Slough were getting sights on goal but some great defending from Lancing was ensuring the ball was not reaching Evans.
With less than ten minutes remaining, Slough extended their lead through the fortune of an own goal. Swift was played into space down the left and hung a ball up to the back post. Dave Sharman was caught in two minds and the ball struck his knee and back towards goal and narrowly over the line.
Lancing now continued to push forwards to try and bring themselves back into the game, but it was Slough who got the game's final goal as a Swift corner was headed home at the far post by Rebels captain Yeboah.
Slough will now travel to Erith Town for the next round, after the side received a bye following the withdrawal of Ashford Town from footballing competitions in the 2010/2011 season.
Lancing Line up
Matt Evans, Like Migmall, Chris Hibberd, Dave Sharman, Mike Hemsley, John Elliott, Jack Hayward, Dan McLoughlin, Lee Garnham, Michael Simms, Dan Turner. Subs: Wayne Joseph, Gareth Green, Peter Proto, Les Gibbs, Dan Griffin, Adam Brodrick, Darren Annis