Slough had the better of the chances in the first half, and it looked as if half-time would arrive without a goal, in a repeat of the Burnham game the previous Tuesday.
Nathan Bowden-Haase had a header and a rebound blocked on the line, and Tyrone Sealey, a replacement for the injured Chris Herron, fired a yard over the bar after a mazy dribble. Herron would later leave Holloways Park on crutches.
Tommy Hayes found himself clean through after Sealey played him in, but he took too much time on the ball and ex-Rebel Michael Parkin was able to make a brave stop.
Barton Rovers did enjoy a few spells of decent possession, but too often the final ball was lacking and the visitors were restricted to long shots.
Bowden-Haase saw another free header cleared off the line before Slough did eventually take the lead in the 42nd minute. A mix-up at the back saw two defenders collide and Hayes profited, coolly slotting the ball through Parkin's legs and into the back of the net.
Just before the half-time whistle, Slough doubled their lead. Bowden-Haase played a fantastic cross-field ball to Sealey on the left, and the winger's cross to the far post was headed in by the Steve Sinclair, who rose well above his marker.
With the comfort of the two-goal cushion, Slough went in search of more goals in the second half. Martin was played in on goal but his placed effort was well saved by Parkin.
Kean and Edgeworth went close before the former won a penalty kick, his shot hitting a defender's hand. Simon Martin stepped up and confidently smashed the ball in off the crossbar, and like Hayes in the first half, registered his first goal for the club.
Barton showed no signs of throwing in the towel though, and pulled one back with Russell Preston lobbing Ricky Perks delightfully from 25 yards.
Slough efforts on goal continued to come coming thick and fast, with Bowden-Haase blazing well over and Paul Edgeworth having a goal ruled out when the ball looked at least a yard over the goal-line. The Rebels were not to be denied a fourth goal though as Hayes nodded in a Sinclair cross following a good team move.
The scoring was concluded with ten minutes to go as Sinclair drilled a shot across Parkin into the bottom corner.
Barton Rovers Line up
1. Michael Parkin, 2. Luke Jones, 3. Ricky Case, 4. Ross Hanley, 5. Joe Corrie, 6. Tawhid Juneja (c), 7. Ashley Daneils, 8. Raymond Antcliff, 9. Richard Pringle, 10. Joel Mason, 11. Russell Preston. Subs: 12. Paul Andrews, 14. Peter Duffy, 15. Danny Watson, 16. Joe Bradbury, 17. Simon Chang.